Skip to main content

deployment

Mentors and Regional Facilitators
Name Region Skills Interests
Michael Blackmon Campus Champions, ACCESS CSSN
Brian Haymore Campus Champions, RMACC, CCMNet
Charles Forsyth Campus Champions
Cody Stevens Campus Champions, CCMNet
Edwin Posada Campus Champions
Jeff Falgout Campus Champions, RMACC
Jack Garmer Campus Champions
Michael Schnaitter ACCESS CSSN
Ric Anderson Campus Champions
Sumit Saluja Campus Champions
Timothy Middelkoop ACCESS CSSN, Campus Champions, CCMNet, Great Plains
Users
There are no Users associated with this topic. View All People.
Blog Entries
There are no Blog Entries associated with this topic.

Affinity Groups

There are no Affinity Groups associated with this topic. View All Affinity Groups.

Announcements

There are no announcements with this tag. View All Announcements.

Upcoming Events & Trainings

No events or trainings are currently scheduled.

Topics from Ask.CI

Loading topics from Ask.CI ...

Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Charles Forsyth

University of California, Riverside

Programs

Campus Champions

Roles

regional facilitator, research computing facilitator

Charles Forsyth headshot

Expertise

Edwin Posada

Temple University

Programs

Campus Champions

Roles

research computing facilitator

Profile Image

Expertise

Calloway Sutton

Indiana University

Programs

ACCESS CSSN

Roles

cssn

Placeholder headshot

Expertise

People with Interest

Matthew Chung

University of California Riverside

Programs

Campus Champions

letter_m

Interests

William Lai

Cornell University

Programs

ACCESS CSSN

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, ci systems engineer, Consultant

William KM Lai

Interests

Timothy Middelkoop

Internet2

Programs

ACCESS CSSN, Campus Champions, CCMNet, Great Plains

Roles

mentor, regional facilitator, researcher/educator, research computing facilitator, CCMNet

Timothy Middelkoop (white male with short dark hair and glasses, he/him,his)

Interests