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deployment

Mentors and Regional Facilitators
Name Region Skills Interests
Michael Blackmon Campus Champions, ACCESS CSSN
Brian Haymore Campus Champions, RMACC, CCMNet
Charles Forsyth Campus Champions
Cody Stevens Campus Champions, CCMNet
Daniel Benedict CCMNet
Edwin Posada Campus Champions
Jeff Falgout Campus Champions, RMACC
Jack Garmer Campus Champions
Michael Schnaitter ACCESS CSSN
Ric Anderson Campus Champions
Sumit Saluja Campus Champions
Timothy Middelkoop ACCESS CSSN, Campus Champions, CCMNet, Great Plains
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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Anton Semenchenko

Programs

CCMNet

Roles

CCMNet

Placeholder headshot

Expertise

Brian Haymore

University of Utah

Programs

Campus Champions, RMACC, CCMNet

Roles

mentor, research computing facilitator, ci systems engineer, CCMNet

Brian Haymore

Expertise

Cody Stevens

Wake Forest University

Programs

Campus Champions, CCMNet

Roles

regional facilitator, researcher/educator, research computing facilitator, ci systems engineer, CCMNet

Cody Stevens

Expertise

People with Interest

Gretta Kellogg

Pennsylvania State University

Programs

ACCESS CSSN

Roles

cssn

Placeholder headshot

Interests

+26 more tags

Matthew Chung

University of California Riverside

Programs

Campus Champions

letter_m

Interests

Timothy Middelkoop

Internet2

Programs

ACCESS CSSN, Campus Champions, CCMNet, Great Plains

Roles

mentor, regional facilitator, researcher/educator, research computing facilitator, CCMNet

Timothy Middelkoop (white male with short dark hair and glasses, he/him,his)

Interests