deployment
Mentors and Regional Facilitators
| Name | Region | Skills | Interests |
|---|---|---|---|
| Michael Blackmon | Campus Champions, ACCESS CSSN | ||
| Brian Haymore | Campus Champions, RMACC, CCMNet | ||
| Charles Forsyth | Campus Champions | ||
| Cody Stevens | Campus Champions, CCMNet | ||
| Daniel Benedict | CCMNet | ||
| Edwin Posada | Campus Champions | ||
| Jeff Falgout | Campus Champions, RMACC | ||
| Jack Garmer | Campus Champions | ||
| Michael Schnaitter | ACCESS CSSN | ||
| Ric Anderson | Campus Champions | ||
| Sumit Saluja | Campus Champions | ||
| Timothy Middelkoop | ACCESS CSSN, Campus Champions, CCMNet, Great Plains |
Users
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Projects
| Project Title | Project Institution | Project Owner | Tags | Status |
|---|---|---|---|---|
| Simulating 21st century boreal forests and fire with a state-of-the-art process-based model | Cary Institute | Winslow Hansen | biology, cluster-support, dependencies, deployment, netcdf, performance-tuning, r | Finishing Up |
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Containerized Jupyter Notebooks for HPCs | Learning | cloud, cloud-computing, openstack, scratch, data-management, data-reproducibility, github, workflow, open-ondemand, administering-hpc, configuration-automation, hpc-getting-started, hpc-tools, deployment, scripting, conda, jupyterhub, programming-best-practices, python, mpi, containers, docker, singularity | Intermediate |
Engagements
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress
People with Expertise
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People with Interest
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Manas Vishal
University of Massachusetts, Dartmouth
Programs
CAREERS, Northeast, CCMNet
Roles
student-facilitator, CCMNet
Interests
