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cpu-architecture

Mentors and Regional Facilitators
Name Region Skills Interests
Adam Carlson Campus Champions
Charles Forsyth Campus Champions
Cody Stevens Campus Champions, CCMNet
Chris Reidy Campus Champions, CCMNet
Daniel Benedict CCMNet
Deborah Penchoff Campus Champions
Elizabeth Leake CCMNet
Jeff Falgout Campus Champions, RMACC
Julie Ma ACCESS CSSN, At-Large, Campus Champions, CAREERS, CCMNet, Northeast
James Hutcheson Campus Champions, ACCESS CSSN
Michael Schnaitter ACCESS CSSN
Ron Rahaman Campus Champions
Ruben Lara Campus Champions
Liwen Shih Campus Champions, ACCESS CSSN, CCMNet
Steven Kuhlo TRECIS
Thomas Pranzatelli
Trey Breckenridge Campus Champions
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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Anton Semenchenko

Programs

CCMNet

Roles

CCMNet

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Expertise

Calloway Sutton

Indiana University

Programs

ACCESS CSSN

Roles

cssn

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Expertise

Steven Kuhlo

UT Dallas

Programs

TRECIS

Roles

mentor

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Expertise

People with Interest

Jeevesh Choudhury

Arizona State University

Programs

CCMNet

Roles

student-facilitator, research software engineer, CCMNet

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Interests

Dylan Perkins

Other

Programs

ACCESS CSSN, RMACC

Roles

mentor, regional facilitator, research computing facilitator

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Interests

Matthew Chung

University of California, Riverside

Programs

ACCESS CSSN, CCMNet

Roles

research computing facilitator, ci systems engineer, cssn, CCMNet

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Interests