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generative-ai

Mentors and Regional Facilitators
Name Region Skills Interests
Aniruddha Maiti ACCESS CSSN, Campus Champions
Devin Bayly ACCESS CSSN, Campus Champions, CCMNet
Brandon Biggs OnDemand
David Liu CCMNet
David Ryglicki
Fan Chen ACCESS CSSN
Feseha Abebe-Akele CCMNet
Mattie Niznik Campus Champions
Dr. Nabeel Alzahrani Campus Champions, CCMNet
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Topics from Ask.CI

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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Devin Bayly

University of Arizona

Programs

ACCESS CSSN, Campus Champions, CCMNet

Roles

research computing facilitator, Affinity Group Leader, CCMNet

User

Expertise

Fan Chen

Programs

ACCESS CSSN

Roles

mentor, cssn, CIP

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Expertise

Gulustan Dogan

University of North Carolina, Wilmington

Programs

ACCESS CSSN, CCMNet

Roles

cssn, CIP, CCMNet

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Expertise

People with Interest

Juanjo Garcia Mesa

Arizona State University

Programs

Campus Champions, CCMNet, ACCESS CSSN

Roles

mentor, CampusChampionsAdmin, research computing facilitator, research software engineer, cssn, Affinity Group Leader, CCMNet

Profile picture of Juanjo Garcia Mesa

Interests

Sanju Timsina

Programs

CCMNet

Roles

CCMNet

S graphic

Interests

David Liu

Purdue University

Programs

CCMNet

Roles

mentor, researcher/educator, research computing facilitator, CCMNet

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Interests