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Mentors and Regional Facilitators
Name Region Skills Interests
Anita Schwartz Campus Champions
Michael Blackmon Campus Champions, ACCESS CSSN
Brian Haymore Campus Champions, RMACC, CCMNet
Kevin Bryan Campus Champions
Christina Divoll Campus Champions, ACCESS CSSN
Cody Stevens Campus Champions, CCMNet
David Liu CCMNet
Yu-Chieh Chi Campus Champions
Jordan Hayes Campus Champions
Juan Vanegas Northeast
Kali McLennan Campus Champions, Great Plains
Katherine Nelson Campus Champions, CAREERS, ACCESS CSSN
James Hutcheson Campus Champions, ACCESS CSSN
Justin Oelgoetz Campus Champions, CCMNet
Paul Rulis Campus Champions
David Reddy Campus Champions
Ric Anderson Campus Champions
Ruben Lara Campus Champions
Steven Kuhlo TRECIS
Sathish Srinivasan ACCESS CSSN
Trey Breckenridge Campus Champions
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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Anita Schwartz

University of Delaware

Programs

Campus Champions

Roles

mentor, research computing facilitator, Affinity Group Leader, steering committee

profile image

Expertise

Jeremy Schafer

Rutgers, the State University of New Jersey

Programs

CCMNet

Roles

CCMNet

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Expertise

Paul Rulis

University of Missouri-Kansas City

Programs

Campus Champions

Roles

researcher/educator, research computing facilitator

Paul Rulis

Expertise

People with Interest

Iman Rahbari

University of Southern California

Programs

Campus Champions, ACCESS CSSN, CCMNet

Roles

mentor, researcher/educator, research computing facilitator, research software engineer, cssn, CCMNet

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Interests

+47 more tags

Devin Bayly

University of Arizona

Programs

ACCESS CSSN, Campus Champions, CCMNet

Roles

research computing facilitator, Affinity Group Leader, CCMNet

User

Interests

Programs

CCMNet

Roles

CCMNet

Interests