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Mentors and Regional Facilitators
Name Region Skills Interests
Aaron Jezghani Campus Champions
Andrew Monaghan ACCESS CSSN
Christopher Bl… Campus Champions
Bala Desinghu ACCESS CSSN, Campus Champions, CAREERS, Northeast
Daniel Howard ACCESS CSSN, Campus Champions, CCMNet, RMACC
Darshan Sarojini ACCESS CSSN
Edwin Posada Campus Champions
Gil Speyer ACCESS CSSN, RMACC, Campus Champions
Jeff Falgout Campus Champions, RMACC
Jonathan Komperda Campus Champions
Jason Wells ACCESS CSSN, Campus Champions
Jason Yalim Campus Champions
Katia Bulekova ACCESS CSSN, Campus Champions, CAREERS, CCMNet, Northeast
Mohsen Ahmadkhani CCMNet, ACCESS CSSN
Mohammadreza H… Campus Champions
Michael Puerrer Campus Champions, Northeast
Maryam Taeb
Justin Oelgoetz Campus Champions, CCMNet
Paul Rulis Campus Champions
Rebecca Belshe Campus Champions, CCMNet
Ron Rahaman Campus Champions
Xiaoqin Huang ACCESS CSSN
Liwen Shih Campus Champions, ACCESS CSSN
Xiaoge Wang Campus Champions
Users
Name Roles Skills Interests
Amin Sepehri
student facilitator
Joseph Antonucci
student facilitator
Bala Desinghu
mentor
researcher/educator
rcf
Katia Bulekova
mentor
rcf
Nihar Biradar
student facilitator
Parameshwaran …
student facilitator
Sanguthevar Ra…
researcher/educator
Stanley Nwoji
researcher/educator
Ying-Chih Sun
student facilitator
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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Doruk Alp MUTLU

Michigan State University

Programs

ACCESS CSSN

Roles

student-facilitator

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Expertise

Xiaoqin Huang

Rice University

Programs

ACCESS CSSN

Roles

mentor, research computing facilitator, research software engineer, cssn

xqhuang at Rice

Expertise

Liwen Shih

University of Houston-Clear Lake

Programs

Campus Champions, ACCESS CSSN

Roles

research computing facilitator, cssn

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Expertise

People with Interest

Matt Ferguson

Boise State University

Programs

At-Large

Roles

researcher/educator, cssn

picture of Matt Ferguson

Interests

Mohsen Ahmadkhani

Programs

CCMNet, ACCESS CSSN

Roles

student-facilitator, mentor, cssn, CCMNet

Mohsen Ahmadkhani

Interests

Matthew Chung

University of California, Riverside

Programs

ACCESS CSSN, CCMNet

Roles

research computing facilitator, ci systems engineer, cssn, CCMNet

Placeholder headshot

Interests